| e00 | Exchange file (Arc/Info) |
| EBJ | Error Checking Object file (Geoworks) |
| ED5 | EDMICS image |
| ED6 | EDMICS image |
| EDA | Ensoniq ASR disk image |
| EDB | ROOTS3 Geneological data file |
| EDE | Ensoniq EPS disk image |
| EDD | Element Definition document (FrameMaker+SGML documents) |
| EDK | Ensoniq KT disk image |
| EDQ | Ensoniq SQ1/SQ2/KS32 disk image |
| EDS | Ensoniq SQ80 disk image |
| EDT | Default settings (VAX Edt editor) |
| EDV | Ensoniq VFX-SD disk image |
| EEB | Button Bar for Equation editor (Microsoft WordPerfect for Windows) |
| EFA | Ensoniq ASR file |
| EFE | Ensoniq EPS file |
| EFK | Ensoniq KT file |
| EFQ | Ensoniq SQ1/SQ2/KS32 file |
| EFS | Ensoniq SQ80 file |
| EFT | High Resolution Screen Font (ChiWriter) |
| EFV | Ensoniq VFX-SD file |
| EFX | Fax Document (Everex EFax) |
| EFX | Fax document (Efax Reader) |
| EGA | EGA Display font (Ventura Publisher) |
| EKM | Keyboard macro definitions file (EXP: The Scientific Word Processor) |
| EL | Lisp Source code (eMacs) |
| ELC | eMac Lisp Source code (byte-compiled) |
| ELM | Theme-Pack file for (Microsoft FrontPage) |
| ELT | Event List Text file (Prosa) |
| EMB | Embedded bank File (Everest) |
| EMD | ABT Extended MoDule |
| EMF | Enhanced Windows Metafile |
| EML | Microsoft Outlook Express mail message (MIME RFC 822) |
| EMS | Enhanced Menu System Configuration file (PC Tools) |
| EMU | Terminal Emulation Data file (BITCOM) |
| ENC | Music file (Encore) |
| ENC | Video file |
| ENC | Encoded file (UUENCODEd File, Lotus 1-2-3) |
| END | Arrow-Head Definition Table (CorelDraw) |
| ENFF | Neutral Format |
| ENG | Dictionary Engine file (Sprint) |
| ENG | Chart Graphics file (EnerGraphics) |
| ENV | Enveloper Macro (WOPR) |
| ENV | Environment file (Microsoft WordPerfect for Windows) |
| EPD | Publication file (Express Publisher) |
| EPHTML | Enhanced Perl-parsed HTML |
| EPI | Document file (Express Publisher) |
| EPS | Encapsulated Postscript Vector graphics (Adobe Illustrator) |
| EPS | Printer font (Epson, Xerox, Ventura Publisher) |
| EPS2 | Adobe Level II Encapsulated Postscript |
| EPS | Encapsulated PostScript image file |
| EPSF | Encapsulated PostScript |
| EPSI | Adobe Encapsulated Postscript Interchange |
| EQN | Equation file (Microsoft WordPerfect for Windows) |
| ER1 | ERWin file |
| ERD | Entity Relationship Diagram graphic file (Prosa) |
| ERM | Entity Relationship Diagram Model file (Prosa) |
| ERR | Stores the error messages that result when the RoboHELP Help Compiler attempts to compile the source files of a Help system |
| ERR | Compilation error file (Microsoft Visual FoxPro) |
| ERX | ERWin file |
| ESF | Audio file (Emblaze) |
| ESH | Extended Shell Batch file (DOS) |
| ESL | Distributable support library file (Microsoft Visual FoxPro) |
| ESPS | ESPS audio file |
| ESS | Style sheet (EXP: The Scientific Word Processor) |
| ETH | Document file (Ethnograph 3.x) |
| ETX | Structure Enhanced text (SetText) |
| EUI | Ensoniq ESP family compacted disk image |
| EVT | Event Log (Microsoft Windows NT, 2000) |
| EVY | Document (Microsoft Wordperfect for Windows Envoy) |
| EWD | Text Document (Express Publisher for Windows) |
| EWL | Microsoft Encarta document |
| EXT2 | Second extended file system (Linux) |
| EXT3 | Third extended file system (Linux) |
| EX3 | Device Driver file (Harvard Graphics 3.x) |
| EXC | Microsoft Word Exclusion Dictionary file |
| EXC | Source Code file (Rexx VM/CMS) |
| EXC | Exclude file for Optimize (do not process, QEMM) |
| EXE | Executable file (program) |
| EXP | Saved chat (ICQ) |
| EXT | ASCII binary transfer file (WS_FTP PRO) (IPSWITCH Software) |
| EZP | Compressed file (Edify.zip) (Edify Electronic Workforce Backup Utility) |
| E00 | Coverage export file (ArcInfo) |
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